NAC (N-acetyl-cysteine) NAC, a sulfur-containing derivative of the amino acid L-cysteine, supports antioxidant and detoxification mechanisms in the body. NAC supports antioxidant activity by neutralizing hydrogen peroxide, hypochlorous acid, and the highly reactive hydroxyl radical and also serves as a source of sulfhydryl groups. In addition, NAC enhances the production of glutathione—a key component of both antioxidant and detoxification enzymes.*

NAC is recognized for its support of normal mucous production and may positively support respiratory function and eye health, especially when consumed over a prolonged period. Research suggests that NAC may protect cell and tissue health by supporting normal metal status in the body.*

Glutathione While the absorption of oral glutathione may be limited, supplementation with NAC may significantly increase circulating levels of glutathione in the body. Once NAC promotes the production of glutathione, glutathione is incorporated into crucial antioxidant enzymes (e.g., glutathione peroxidase and glutathione reductase) and detoxification enzymes (glutathione S-transferases). Through the activity of these enzymes, glutathione directly supports antioxidant activity, phase II detoxification, and the normal breakdown of metabolites, toxins, and other compounds in the body. Glutathione also participates in fatty acid synthesis and amino acid transport across the cell membrane.*

A variety of factors may determine glutathione requirements, including the level of exposure to toxins, increased phase I detoxification activity, and the overall need for antioxidant support. Maintaining glutathione levels may be important to maintaining the health of the respiratory, hepatic, and immune systems, as well as supporting antioxidant protection of lipids and proteins and supporting the normal response to inflammation. Levels of endogenous antioxidants, including glutathione, may decrease with age. It is important to maintain adequate levels of glutathione in the body to support overall health and well-being throughout the lifespan.*